One-Pot, Surfactant-Free Synthesis of Gold Nanostars and Evaluation of Their Antibacterial Effects against Propionibacterium acnes

Anisotropic gold nanoparticles, especially nanostars, are used in many fields of biomedical applications such as sensing, targeted drug delivery, and diagnostic photothermal therapy. In this study, we introduced a novel application nanostars an antimicrobial agent. While spherical nanoparticles have inappreciable effect, exhibit significant antibacterial activity. Besides, the seed-mediated method, conventional technique for preparing is rather complex toxic to human environment due unsafe synthesized materials surfactants reducers. recent years, green chemistry nanoparticle synthesis attractive because its advantages. Instead procedure, present facile procedure synthesize using ascorbic acid reductant chitosan directing-growth The influences reacting parameters were evaluated determine optimal conditions. Star-shaped successfully with average size tunning from 137.0 ± 20.7 nm id="M2"> 281.9 25.8 core id="M3"> 14.0 4.4 id="M4"> 54.2 11.9 branches. Antibacterial activity against Propionibacterium acnes was also investigated. one main reasons causing acne vulgaris. test by plate count well diffusion method. results showed effect that could be prospective agent replacing antibiotics treatment.